Publications by authors named "Mariana Baptista Tablas"
Capsaicin (CPS, 8-methyl-N-vanillyl-trans-6-nonenamide), a pungent alkaloid from chili peppers, has contradictory effects in both experimental and human carcinogenesis. Thus, we evaluated the modifying effects of chronic CPS during the promotion and progression stages of rat colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Male Wistar rats were given four subcutaneous injections of DMH (40 mg/body weight (b.
View Article and Find Full Text PDFCapsaicin (CPS), an ingredient of plants, has anti-inflammatory, antioxidant and antitumoral properties. The mechanisms of CPS on hepatocarcinogenesis preclinical bioassays are not described. Thus, the protective effects CPS were evaluated in the early stages of chemically-induced hepatocarcinogenesis.
View Article and Find Full Text PDFEarly molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development.
Toxicol Lett
September 2020
Article Synopsis
- The study explored the early cellular and molecular changes in the colon and liver of male Wistar rats after exposure to 1,2-dimethylhydrazine (DMH), focusing on its effects on cancer development over time.
- Short-term exposure to DMH increased markers of genotoxicity, cell proliferation, and apoptosis, while decreasing antioxidant activity in both organs, indicating oxidative stress.
- In the medium-term study, a significant increase in preneoplastic lesions in the colon was observed, along with a few hepatic foci, suggesting that both the liver and colon play important roles in the early stages of colon cancer development induced by DMH.*
Article Synopsis
- Capsaicin, the compound that makes chili peppers spicy, has shown mixed results regarding its potential to cause cancer, with some studies indicating it might help prevent cancer while others suggest possible risks at high doses.
- The study evaluated the effects of capsaicin on colon cancer induced by DMH in male Wistar rats, finding that capsaicin promoted anti-cancer effects by influencing genes related to apoptosis and cell differentiation.
- Results indicated that capsaicin reduced the number of abnormal cell formations (ACF) in the colon, suggesting it may help prevent colon cancer, despite no significant differences in tumor occurrence among the tested groups.
This study aimed the integrative characterization of morphological, biochemical and molecular features of chemically-induced cirrhosis-associated hepatocarcinogenesis. Thus, male Wistar rats were submitted to a diethylnitrosamine (DEN)/thioacetamide (TAA)-induced model. Liver tissue was processed for global gene expression, histopathological and collagen evaluations; as well as immunohistochemical and oxidative stress analysis.
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