Publications by authors named "Mariana B de Abreu"
Article Synopsis
- Cylindrospermopsin (CYN) is a harmful cyanotoxin that poses increasing risks to human health, particularly affecting the lungs.
- In a study using male BALB/c mice, the effects of CYN were assessed alongside treatments with the anti-inflammatory drug dexamethasone to see if it could alleviate the damage caused by CYN.
- Results showed that CYN led to worsened lung mechanics and inflammation, but treatment with dexamethasone helped to reverse some of these negative effects.
Laparoscopic surgery with pneumoperitoneum increases respiratory system elastance due to the augmented intra-abdominal pressure. We aim to evaluate to which extent positive end-expiratory pressure (PEEP) is able to counteract abdominal hypertension preventing progressive lung collapse and how rib cage elastance influences PEEP effect. Forty-four Wistar rats were mechanically ventilated and randomly assigned into three groups: control (CTRL), pneumoperitoneum (PPT) and pneumoperitoneum with restricted rib cage (PPT-RC).
View Article and Find Full Text PDFVariable Ventilation Associated With Recruitment Maneuver Minimizes Tissue Damage and Pulmonary Inflammation in Anesthetized Lung-Healthy Rats.
Anesth Analg
September 2018
Background: Recruitment maneuver and positive end-expiratory pressure (PEEP) can be used to counteract intraoperative anesthesia-induced atelectasis. Variable ventilation can stabilize lung mechanics by avoiding the monotonic tidal volume and protect lung parenchyma as tidal recruitment is encompassed within the tidal volume variability.
Methods: Forty-nine (7 per group) male Wistar rats were anesthetized, paralyzed, and mechanically ventilated.