Bloodstream infection in pediatric patients with febrile neutropenia induced by chemotherapy.

Introduction: Febrile neutropenia (FN) is a serious complication of cancer chemotherapy. The present study aimed to identify risk factors for documented infection in pediatric patients with FN and cancer.

Methods: This prospective cohort study included patients under 18 years from 2016 to 2018.

Serum levels of vancomycin: is there a prediction using doses in mg/kg/day or m(2)/day for neonates?

Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m(2)/day.