Publications by authors named "Mariana Anghel"
Article Synopsis
- A systematic review was conducted to analyze the impact of short-term ozone exposure on COVID-19 transmission and progression, covering studies from January 2020 to January 2023.
- The review identified 18 relevant studies across eight countries, revealing a mixed association between ozone levels and COVID-19 incidence, severity, and mortality.
- Results indicated that while some studies showed higher ozone exposure linked to increased COVID-19 cases, severity, and deaths, others reported negative or no significant associations, suggesting a nuanced relationship that may vary by region.
Purpose: Coronavirus disease is a global pandemic with millions of confirmed cases and hundreds of thousands of deaths worldwide that continues to create a significant burden on the healthcare systems. The aim of this study was to determine the patient clinical and paraclinical profiles that associate with COVID-19 unfavourable outcome and generate a prediction model that could separate between high-risk and low-risk groups.
Patients And Methods: The present study is a multivariate observational retrospective study.
Article Synopsis
- There is growing interest in plant-based drugs due to the rising rates of melanoma and skin cancer, with pentacyclic lupane-type triterpenes showing significant pharmacological benefits.
- Betulin, a compound found in the bark of Betula pendula Roth, has promising antitumor activities but suffers from poor water solubility, which can be enhanced through complexation with cyclodextrins.
- Using a novel cyclodextrin derivative significantly improves betulin's solubility and stability, leading to better pharmacological performance as demonstrated through various testing methods in vitro and in vivo.
Estrogens represent risk factors for endocrine-related cancers and play also an important role in the development and progression of other malignancies. In order to analyze the associations between estrogen receptor gene alpha polymorphisms and cancers susceptibility, we genotyped six single nucleotide polymorphisms (SNPs) in 163 Caucasian cancer patients--103 breast cancers and 60 other malignancies (colorectal, bladder, hepatocellular carcinoma and acute myeloid leukemia)--and 114 healthy controls using hybridization probes. We performed Armitage`s association trend-test to evaluate the risk.
View Article and Find Full Text PDFBackground: IL-17 expression was found to be associated with many inflammatory diseases in humans, such as rheumatoid arthritis, asthma, systemic lupus erythematosus and allograft rejection and many in vitro studies have indicated a proinflammatory function for IL-17.
Objective: Prognostic value of increased serum IL-17 in asthma patients.
Methods: Serum IL-17 (ELISA) was measured in 85 asthma patients (pts), mean age 46.
Antinuclear antibodies in asthma patients- a special asthma phenotype?
Iran J Allergy Asthma Immunol
March 2009
Several studies reported the appearance of asthma and autoimmune conditions in the same patient, but the clinical significance of this association was not yet assessed. One hundred asthmatic patients were observed for one year evolution with death, severe exacerbations, intake of > 1000 micrograms of beclometasone or equivalent (high ICS) and FEV1 decline >100 ml, in relation with ANA (ELISA), sputum and blood eosinophilia (EO), NSAID intolerance, BMI >25, chronic rhinosinusitis, smoking status and FEV1 <30% predicted (low FEV1). After 1 year of observation, there were 5 deaths, 28 severe asthma exacerbations requiring hospitalisations, 24 cases requiring high inhaled corticosteroid intake, and 19 patients with fast FEV1 decline (>100 ml/year).
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