Salinity and prolactin regulate in the model teleost, .

To maintain internal ion balance in marine environments, teleost fishes leverage seawater (SW)-type ionocytes to actively secrete Na and Cl into the environment. It is well established that SW-type ionocytes use apically expressed cystic fibrosis transmembrane conductance regulator 1 (Cftr1) as a conduit for Cl to exit the gill. Here, we investigated whether the Ca-activated Cl channel, anoctamin 1 (Ano1), provides an additional path for Cl-secretion in euryhaline mummichogs ().