Publications by authors named "Marian Pigera"
Purpose: Androgen receptor (AR) and AR signaling pathways are thought to play a role in breast cancer (BC) and are potentially related to treatment responses and outcomes. Ankyrin 3 (ANK3) is associated with AR stability in cancer cells. In the present study, we investigated the clinicopathological utility of ANK3 expression with emphasis on AR and its associated signalling pathway at transcriptomic and proteomic phases.
View Article and Find Full Text PDFBackground: Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and, therefore, may play a key role in carcinogenesis and metastasis. We, herein, investigated the biological and clinical significance of RAPH1 in breast cancer using large annotated cohorts.
Methods: The clinicopathological and prognostic significance of RAPH1 was assessed at the genomic and transcriptomic levels using The Cancer Genome Atlas (TCGA) dataset (n = 1039) and the results were validated using the Molecular taxonomy of breast cancer international consortium (METABRIC) cohort (n = 1980).
Article Synopsis
- The study investigates the role of KLHL7 protein in breast cancer (BC), focusing on its impact on ubiquitination and the progression of tumors.
- It evaluates data from nearly 2,000 patients and validates findings with over 5,200 cases, analyzing the relationship between KLHL7 expression, gene alterations, and clinical outcomes.
- Results indicate that high KLHL7 expression is associated with aggressive tumor characteristics and shorter survival, suggesting it could serve as an independent prognostic marker in breast cancer.
Aims: The recent American Society of Clinical Oncology/College of American Pathologists guidelines for human epidermal growth factor receptor 2 (HER2) testing in breast cancer recommend repeat testing based on tumour grade, tumour type, and hormone receptor status. The aim of this study was to test the value of these criteria.
Methods And Results: HER2 status was concordant in the core biopsies and excision specimens in 392 of 400 invasive carcinomas.