Publications by authors named "Marian Martinez de Pancorboa"
P14ARF gene alterations in human hepatocellular carcinoma.
Monica Anzola Nerea Cuevas Monica López-Martínez Alberto Saiz Juan José Burgos Marian Martínez de Pancorboa
Eur J Gastroenterol Hepatol
January 2004
Introduction: The molecular status of the p14(ARF) gene has not been fully elucidated in hepatocellular carcinoma (HCC). This study was performed to determine genetic and epigenetic alterations in the p14(ARF) tumor suppressor gene and their effect on HCC progression.
Methods: The status of p14 was evaluated in 117 HCC tumoral nodules and 110 corresponding non-tumor tissues by loss of heterozygosity at the 9p21-22 region, homozygous deletions, single strand conformation polymorphism-polymerase chain reaction mutational analysis and methylation-specific polymerase chain reaction.