Parenting, corpus callosum, and executive function in preschool children.

In this longitudinal population-based study (N = 544), we investigated whether early parenting and corpus callosum length predict child executive function abilities at 4 years of age. The length of the corpus callosum in infancy was measured using postnatal cranial ultrasounds at 6 weeks of age. At 3 years, two aspects of parenting were observed: maternal sensitivity during a teaching task and maternal discipline style during a discipline task.

The prevalence of child maltreatment in the Netherlands across a 5-year period.

The prevalence of child maltreatment in the Netherlands was in 2005 first systematically examined in the Netherlands' Prevalence study on Maltreatment of children and youth (NPM-2005), using sentinel reports and substantiated CPS cases, and in the Pupils on Abuse study (PoA-2005), using high school students' self-report. In this second National Prevalence study on Maltreatment (NPM-2010), we used the same three methods to examine the prevalence of child maltreatment in 2010, enabling a cross-time comparison of the prevalence of child maltreatment in the Netherlands. First, 1,127 professionals from various occupational branches (sentinels) reported each child for whom they suspected child maltreatment during a period of three months.

A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans.

Variation in the oxytocin receptor (OXTR) gene may partly explain individual differences in oxytocin-related social behavior. Two single nucleotide polymorphisms (SNPs) have been suggested as promising candidates: rs53576 and rs2254298, although the results of studies were not consistent. We carried out meta-analyses for these two SNPs, covering five domains of outcomes: (a) biology, (b) personality, (c) social behavior, (d) psychopathology, and (e) autism, on the basis of 82 pertinent effect sizes, 48 for OXTR rs53576 (N=17 559) and 34 for OXTR rs2254298 (N=13 547).

Against all odds: genocidal trauma is associated with longer life-expectancy of the survivors.

Does surviving genocidal experiences, like the Holocaust, lead to shorter life-expectancy? Such an effect is conceivable given that most survivors not only suffered psychosocial trauma but also malnutrition, restriction in hygienic and sanitary facilities, and lack of preventive medical and health services, with potentially damaging effects for later health and life-expectancy. We explored whether genocidal survivors have a higher risk to die younger than comparisons without such background. This is the first population-based retrospective cohort study of the Holocaust, based on the entire population of immigrants from Poland to Israel (N = 55,220), 4-20 years old when the World War II started (1939), immigrating to Israel either between 1945 and 1950 (Holocaust group) or before 1939 (comparison group; not exposed to the Holocaust).

Maternal overreactive sympathetic nervous system responses to repeated infant crying predicts risk for impulsive harsh discipline of infants.

Physiological reactivity to repeated infant crying was examined as a predictor of risk for harsh discipline use with 12-month-olds in a longitudinal study with 48 low-income mother-infant dyads. Physiological reactivity was measured while mothers listened to three blocks of infant cry sounds in a standard cry paradigm when their infants were 3 months old. Signs of harsh discipline use were observed during two tasks during a home visit when the infants were 12 months old.

Robust patterns and individual variations: stability and predictors of infant behavior in the still-face paradigm.

In the present study we examined key issues regarding infant behavior in the still-face paradigm (SFP) in terms of individual variations, stability, and predictors. The sample consisted of 115 mothers and infants, with assessments at ages 3 and 6 months, including observations of maternal and infant behavior in the SFP, and parent reports of infant temperament. Both robust patterns and individual variations in infant SFP behaviors were found, with only a minority of infants showing the expected patterns for negative affect and gaze.

The development of adolescents' internalizing behavior: longitudinal effects of maternal sensitivity and child inhibition.

Internalizing symptoms such as withdrawn and anxious-depressed behavior are common in adolescence. This prospective longitudinal study helps to gain insight into the development of internalizing behavior, focusing on the role of early parent-child interaction while ruling out genetic similarity as a confounder. More specifically, the central question addressed in this study was whether parental sensitivity and child inhibited temperament predict children's withdrawn and anxious-depressed behavior in middle childhood and adolescence.

The prevalence of child sexual abuse in out-of-home care: a comparison between abuse in residential and in foster care.

We investigated the 2010 year prevalence of child sexual abuse (CSA) in residential and foster care and compared it with prevalence rates in the general population. We used two approaches to estimate the prevalence of CSA. First, 264 professionals working in residential or foster care (sentinels) reported CSA for the children they worked with (N = 6,281).

No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior.

Objective: Maternal antenatal anxiety is associated with an increased risk of behavioral disturbances in offspring. Recent work has suggested that the effect of maternal antenatal anxiety on infant temperament at 6 months is moderated by the serotonin transporter polymorphism 5-HTTLPR, with carriers of the short allele more susceptible to the adverse behavioral outcomes of maternal antenatal anxiety. These findings, however, are yet to be replicated and extended beyond infancy.

Is elevated risk of child maltreatment in immigrant families associated with socioeconomic status? Evidence from three sources.

In this study we tested whether children from Dutch-immigrant families are at increased risk for maltreatment, and if so, what factors could explain this risk. Three data sources from the second Netherlands Prevalence Study of Maltreatment of Youth (NPM-2010) were used to answer these questions. First, 1127 professionals from various occupational branches (sentinels) were asked to report each child (including some background information on the child and family) for whom they suspected child maltreatment during a period of three months.

Child physical abuse and neglect in Kenya, Zambia and the Netherlands: a cross-cultural comparison of prevalence, psychopathological sequelae and mediation by PTSS.

This study compared the prevalence of self-reported childhood physical abuse and neglect and the associated psychopathological sequelae among Kenyan, Zambian, and Dutch university students. In addition, we sought to find out the differentiated role of posttraumatic stress symptoms (PTSS) in mediating the associations between childhood maltreatment experiences and psychopathology symptoms. The sample consisted of 862 university students from Kenya (n = 375), Zambia (n = 182), and The Netherlands (n = 305) who completed the Personal and Relationships Profile (PRP).

Cultural-geographical differences in the occurrence of child physical abuse? A meta-analysis of global prevalence.

Our comprehensive meta-analysis combined prevalence figures of child physical abuse reported in 111 studies, including 168 independent samples with a total of 9,698,801 participants. The overall estimated prevalence was 3/1000 for studies using informants and 226/1000 for studies using self-report measures of child physical abuse, with no apparent gender differences. Methodological factors partly explained the vast variation of self-reported prevalence rates in individual studies.

Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal.

The neuropeptide oxytocin has been implicated in a variety of social processes. However, recent studies indicate that oxytocin does not enhance prosocial behavior in all people in all circumstances. Here, we investigate effects of intranasal oxytocin administration on intrinsic functional brain connectivity with resting state functional magnetic resonance imaging.

Maternal sensitivity and internalizing problems: evidence from two longitudinal studies in early childhood.

The goal of this study is to clarify the relation between maternal sensitivity and internalizing problems during the preschool period. For this purpose, a longitudinal, bidirectional model was tested in two large prospective, population-based cohorts, the Generation R Study and the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development (NICHD SECCYD), including over 1,800 mother-child dyads in total. Maternal sensitivity was repeatedly observed in mother-child interaction tasks and information on child internalizing problems was obtained from maternal reports.

Does intranasal oxytocin promote prosocial behavior to an excluded fellow player? A randomized-controlled trial with Cyberball.

The neuropeptide oxytocin has been shown to stimulate prosocial behavior. However, recent studies indicate that adverse early caregiving experiences may moderate the positive effects of oxytocin. In this double blind randomized-controlled trial we investigated the effects of oxytocin on prosocial behavior during a virtual ball-tossing game called Cyberball.

Attachment disorganization moderates the effect of maternal postnatal depressive symptoms on infant autonomic functioning.

We examined associations of disorganized attachment and maternal depressive symptoms with infant autonomic functioning in 450 infant-mother dyads enrolled in the Generation R study. Maternal depressive symptoms were measured 2 months postpartum with the Brief Symptom Inventory. At 14 months, we assessed infant attachment with a slightly shortened Strange Situation and measured infant resting heart rate.

Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal Administration.

We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 or 24 IU of oxytocin administration is used. Oxytocin levels were measured in saliva samples collected from 46 female participants right before intranasal administration (at 9:30 a.m.

The impact of oxytocin administration and maternal love withdrawal on event-related potential (ERP) responses to emotional faces with performance feedback.

This is the first experimental study on the effect of oxytocin administration on the neural processing of facial stimuli conducted with female participants that uses event-related potentials (ERPs). Using a double-blind, placebo-controlled within-subjects design, we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial expressions in 48 female undergraduate students. Participants also reported on the amount of love withdrawal they experienced from their mothers.

Salivary α-amylase and intended harsh caregiving in response to infant crying: evidence for physiological hyperreactivity.

This is the first study on adults' physiological reactivity to infant cry sounds and the association with intended harsh parenting using salivary α-amylase (sAA) as a novel and noninvasive marker of autonomic nervous system activity. The sample consisted of 184 adult twin pairs. In an experimental design, cry sounds were presented and adults' perception and their intended caregiving responses were measured.

Attachment in the brain: adult attachment representations predict amygdala and behavioral responses to infant crying.

Current research found that adult attachment representations influence neural, emotional, and behavioral responses to infant crying, thus validating the Berkeley Adult Attachment Interview with functional Magnetic Resonance Imaging. This study examined amygdala activation, feelings of irritation, and the use of excessive force as indicated by grip strength using a handgrip dynamometer during exposure to infant crying and scrambled control sounds in 21 women without children. Individuals with insecure attachment representations showed heightened amygdala activation when exposed to infant crying compared to individuals with secure attachment representations.

The Generation R Study: a review of design, findings to date, and a study of the 5-HTTLPR by environmental interaction from fetal life onward.

Objective: First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal maternal anxiety or postnatal maternal anxiety to influence child emotional development.

Method: A total of 2,136 northern European children were genotyped for 5-HTTLPR and rs25531.

Oxytocin in postnatally depressed mothers: its influence on mood and expressed emotion.

Background: Postnatal depression is common and negatively affects the mother-baby relationship; oxytocin has been found to have positive effects on parenting behavior. We hypothesize that intranasal administration of oxytocin to mothers with depression will influence their parenting related expressed emotion, creating a better basis for sensitive parenting.

Methods: Twenty-five postnatally depressed mothers with infants less than one year participated in a randomized, double-blind, placebo controlled within-subject clinical study in 2011.

Ageing and oxytocin: a call for extending human oxytocin research to ageing populations--a mini-review.

Interest in oxytocin has increased rapidly over the last decades. Consequently, quite a number of studies have addressed the influence of oxytocin on social stress, perception, cognition, and decision making in healthy adults as well as in clinical samples characterized by some form of social disturbance. Surprisingly little research on oxytocin has focused on ageing populations.