Publications by authors named "Mariam Samara"
Article Synopsis
- BPC 157, a stable gastric pentadecapeptide, shows potential in treating major vessel occlusion syndromes by activating collateral pathways and improving venous system function in rats.
- In a study simulating abdominal compartment syndrome, rats receiving BPC 157 had significant recovery from intra-abdominal hypertension and associated complications, including hemorrhagic lesions and brain swelling.
- The treatment prevented serious health issues like severe ECG disturbances, organ congestion, and damage, indicating that BPC 157 effectively cured primary abdominal compartment syndrome.
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and peripherally, with the stable gastric pentadecapeptide BPC 157, which alleviated peripheral vascular occlusion disturbances, rapidly activating alternative bypassing pathways. Assessments were gross recording, venography, ECG, pressure, microscopy, biochemistry.
View Article and Find Full Text PDFAim: To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
Methods: Alongside with the agents' application (after 1 min, medication (/kg, 10 mL/2 min bath/rat) includes: BPC 157 (10 μg), L-NAME (5 mg), L-arginine (100mg) alone or combined, and saline baths (controls)) on the rat perforate cecum injury, we continuously assessed the gross reappearance of the vessels (USB microcamera) quickly propagating toward the defect at the cecum surface, defect contraction, bleeding attenuation, MDA- and NO-levels in cecum tissue at 15 min, and severity of cecum lesions and adhesions at 1 and 7 d.
Results: Post-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO-levels decreased.
Aim: To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
Methods: Medication [BPC 157, L-NAME, L-arginine (alone/combined), saline] was bath at the blood deprived colon segment. During reperfusion, medication was BPC 157 or saline.