Consequences of early extraction of compromised first permanent molar: a systematic review.

Background: The aim of this study was to systematically review the literature to determine the sequelae of early extraction of compromised first permanent molars (FPMs) with regard to the skeletal and dental development of 5- to 15-year-old children. Meta-analysis was conducted when applicable.

Methods: Our research protocol included a search strategy, inclusion/exclusion criteria, and a data extraction plan.