Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population.

In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. Despite ample sunshine, vitamin D deficiency is prevalent (>80%) in the Middle East, resulting in a high rate of supplementation. However, the underlying molecular mechanisms of the specific regimen prescribed and the potential factors affecting an individual's response to vitamin D supplementation are not well characterized.

Receptor D299G/T399I Haplotype Polymorphism Is Associated with Insulin Resistance in Obese Female Subjects.

Background: Activation of Toll-like-receptor 4 () causes chronic inflammation that can result in obesity and metabolic syndrome (MeS).

Aim: This study aimed to investigate the role of polymorphisms of D299G/T399I, and its impact on protein expression of in obese female subjects.

Methodology: A prospective cross-sectional association study was performed on Arab female subjects from Qatar University.