Publications by authors named "Marialva Goncalves"
Na+,K(+)-ATPase activity is reduced in hippocampus of rats submitted to an experimental model of depression: effect of chronic lithium treatment and possible involvement in learning deficits.
Ana Paula Santana de Vasconcellos Alessandra Ioppi Zugno Ana Helena D P Dos Santos Fabiane Batistela Nietto Leonardo Machado Crema
Neurobiol Learn Mem
September 2005
Article Synopsis
- The study investigated how chronic stress and lithium treatments affect Na+,K(+)-ATPase activity in the hippocampus and spatial memory in rats.
- Two experiments were conducted: the first evaluated Na+,K(+)-ATPase activity after a chronic stress protocol coupled with lithium treatment, while the second assessed spatial memory performance in a Water Maze task during and after stress treatment.
- Results showed that chronic stress impaired both Na+,K(+)-ATPase activity and spatial memory, but these impairments were mitigated by lithium treatment and stress interruption, suggesting lithium's role in treating mood disorders may involve regulating this enzyme activity.