Publications by authors named "Mariah Perkins"
Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.
Mayra A Gonzalez Idaly M Olivas Alfonso E Bencomo-Alvarez Andres J Rubio Christian Barreto-Vargas Mariah Perkins
Clin Transl Med
December 2022
Article Synopsis
- Tyrosine kinase inhibitors (TKIs) have transformed chronic myeloid leukaemia (CML) from a deadly condition into a manageable one, but drug-resistant leukaemia stem cells present a significant challenge for achieving a cure.
- A new study highlights the downregulation of the G0/G1 switch gene 2 (G0S2), a key regulator of lipid metabolism, in various instances of TKI resistance, which correlates with poorer survival outcomes for patients.
- The research indicates that the decrease in G0S2 is influenced by transcriptional repression from MYC rather than by genetic changes or BCR::ABL1 activity, suggesting that restoring G0S2 could be crucial for improving treatment responses
Patients with metastatic angiosarcoma undergoing chemotherapy, radiation, and/or surgery experience a median progression free survival of less than 6 months and a median overall survival of less than 12 months. Given the aggressive nature of this cancer, angiosarcoma clinical responses to chemotherapy or targeted therapeutics are generally very poor. Inhibition of beta adrenergic receptor (β-AR) signaling has recently been shown to decrease angiosarcoma tumor cell viability, abrogate tumor growth in mouse models, and decrease proliferation rates in preclinical and clinical settings.
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