Publications by authors named "Mariah L Wright"

Background: Fluid overload leads to poor neonatal outcomes. Diuretics may lower the rates of mechanical ventilation (MV) and mortality in neonates with fluid overload.

Methods: This is a retrospective study of preterm neonates ≤ 36 weeks of gestational age (GA) in the first 14 postnatal days in a level IV NICU in 2014-2020.

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Fertility navigators (FNs) are important in communicating infertility risk and fertility preservation (FP) options to patients receiving gonadotoxic therapies. This retrospective study examined electronic medical records of patients with fertility consults at a large pediatric institution (2017-2019), before and after hiring a full-time FN. Of 738 patient encounters, 173 consults were performed pre-navigator and 565 post-navigator.

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Article Synopsis
  • Sedation is commonly used in pediatric patients with acute lymphoblastic leukemia (ALL) to alleviate pain and anxiety during lumbar punctures, but there are concerns about potential long-term cognitive effects from repeated sedative use.
  • A study was conducted across 48 hospitals to analyze sedation practices among children with ALL receiving chemotherapy, focusing on anesthesia usage.
  • Findings showed that 98.2% of cases used intravenous or inhaled anesthetics, with propofol being the most frequently utilized sedative, indicating a preference for more comprehensive sedation methods in these procedures.
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A three-component drug-delivery system has been developed consisting of multi-walled carbon nanotubes (MWCNTs) coated with a non-classical platinum chemotherapeutic agent ([PtCl(NH)(L)]Cl (P3A1; L=N-(2-(acridin-9-ylamino)ethyl)-N-methylproprionimidamide) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (DSPE-mPEG). The optimized P3A1-MWCNTs are colloidally stable in physiological solution and deliver more P3A1 into breast cancer cells than treatment with the free drug. Furthermore, P3A1-MWCNTs are cytotoxic to several cell models of breast cancer and induce S-phase cell cycle arrest and non-apoptotic cell death in breast cancer cells.

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