Publications by authors named "Mariah J Berner"
Article Synopsis
- Mitochondria are important parts of cells that help with energy and can influence cancer growth and how well treatments work.
- Researchers studied a type of aggressive breast cancer called triple negative breast cancer (TNBC) to understand how the structure of mitochondria changes when treated with chemotherapy.
- They found that chemotherapy can change the shape and size of mitochondria in tumors, differing in treated tumors compared to those that weren't treated, suggesting that understanding these changes could help improve cancer treatment strategies.
"Reprogramming of energy metabolism" was first considered an emerging hallmark of cancer in 2011 by Hanahan & Weinberg and is now considered a core hallmark of cancer. Mitochondria are the hubs of metabolism, crucial for energetic functions and cellular homeostasis. The mitochondrion's bacterial origin and preservation of their own genome, which encodes proteins and RNAs essential to their function, make them unique organelles.
View Article and Find Full Text PDFArticle Synopsis
- * Research showed that residual TNBC cells depend heavily on mitochondrial oxidative phosphorylation (OXPHOS) for survival after treatment, with mitochondrial structure and dynamics influencing this reliance.
- * Using a combination of DNA-damaging chemotherapy to increase mitochondrial fusion and OXPHOS followed by an OPA1 inhibitor successfully suppressed the regrowth of remaining TNBC tumor cells, suggesting a new treatment strategy.