Objective: Use of ampicillin in outpatient parenteral antimicrobial therapy (OPAT) has historically been complicated by frequent dosing and limited stability. The purpose of this study was to evaluate stability of ampicillin using high-pressure liquid chromatography (HPLC) in an OPAT dosing model using continuous infusion at room temperature over 24 hours immediately following preparation compared with batches stored under refrigeration for 24 hours, 72 hours, and 7 days.
Methods: An HPLC method was developed and validated as stability indicating using guidance in USP general Chapter <1225>.
Objectives: To assess labelling accuracy for low nicotine concentration e-cigarette liquids.
Methods: Nicotine concentration in twelve e-liquids, available in 3 and 6 mg/ml strengths, was assayed (5 replicates each) using liquid chromatography-tandem mass spectrometry.
Key Findings: Average nominal concentrations of nicotine were lower than reported in 23/24 products tested, with 2/12 products labelled 3 mg/ml, and 3/12 of the 6 mg/ml products showing statistically significant differences from controls.