Publications by authors named "Mariagrazia Terlizzese"
Human type I interferons are a family of pleiotropic cytokines with antiviral, anti-proliferative and immunomodulatory activities. They signal through the same cell surface receptors IFNAR1 and IFNAR2 yet evoking markedly different physiological effects. One differentiating factor of interferon-beta (IFN-β) from other type I interferons is the presence of theAsn-Gly-Arg (NGR) sequence motif, which, upon deamidation, converts to Asp-Gly-Arg (DGR) and iso-Asp-Gly-Arg (iso-DGR) motifs.
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- Biosimilars are biological products that mimic existing approved products, requiring extensive analysis to demonstrate similarity in structure and function.
- A comparative study was conducted between the proposed biosimilar adalimumab MSB11022 and its reference product, Humira®, using advanced methods to analyze their physicochemical and functional properties across multiple batches.
- Results showed high similarity between MSB11022 and Humira®, with comparable purity and efficacy in functional tests, suggesting that MSB11022 may be as safe and effective as Humira®.
Recombinant human interferon β-1a (IFN-β-1a) is extensively used as the first-line treatment of relapsing forms of multiple sclerosis. Its glycosylation is recognized as having a complex impact on a wide range of molecule characteristics and functions. The present study reports the enrichment of IFN-β-1a glycoforms and their physicochemical and biological characterization by means of electrospray ionization-mass spectrometry, sialic acid content, thermal denaturation and various in vitro bioassays (antiproliferative, antiviral, immunomodulatory and reporter gene assay).
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