Curricular and pedagogical approaches for physical activity prescription training: a mixed-methods study of the "Exercise is Medicine" workshops in Colombia.

Background: The physical activity (PA) prescription workshop for physicians, through the global health initiative "Exercise is Medicine" (EIM), has trained more than 4000 health care professionals (HCPs) in Latin America. It has shown to be effective in increasing PA prescription knowledge and awareness among HCPs. The purpose of this paper is to evaluate the curricular and pedagogical approach used by EIM Colombia at the PA prescription workshops implemented between 2014 and 2015.

Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons.

Emerging evidence highlights the relevance of the protein post-translational modification by SUMO (Small Ubiquitin-like Modifier) in the central nervous system for modulating cognition and plasticity in health and disease. In these processes, astrocyte-to-neuron crosstalk mediated by extracellular vesicles (EVs) plays a yet poorly understood role. Small EVs (sEVs), including microvesicles and exosomes, contain a molecular cargo of lipids, proteins, and nucleic acids that define their biological effect on target cells.

Lack of ApoE inhibits ADan amyloidosis in a mouse model of familial Danish dementia.

The Apolipoprotein E-ε4 allele (APOE-ε4) is the strongest genetic risk factor for late onset Alzheimer disease (AD). ApoE plays a critical role in amyloid-β (Aβ) accumulation in AD, and genetic deletion of the murine ApoE gene in mouse models results in a decrease or inhibition of Aβ deposition. The association between the presence of ApoE and amyloid in amyloidoses suggests a more general role for ApoE in the fibrillogenesis process.

Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group.

Objectives: The objective of this study was to assess the diagnostic performance of combined computerised tomography (CT) and positron emission tomography (PET) in mediastinal staging of surgical lung cancer based on data obtained from the prospective cohort of the Spanish Group for Video-Assisted Thoracic Surgery (GEVATS).

Methods: A total of 2782 patients underwent surgery for primary lung carcinoma. We analysed diagnostic success in mediastinal lymph node staging (cN2) using CT and PET.

Impact of elite soccer coaching change on team performance according to coach- and club-related variables.

A coaching change is an extreme, but frequently occurring phenomenon in elite soccer with its impact on team success debatable. The aim of the current study was twofold: (i) to compare team's performance when coached by new and old coaches; and (ii) to investigate the impact of a coaching change on team's performance according to coach- and club-related factors. All in-season coaching changes from the 2010-11 to 2017-18 seasons within the Spanish, French, English, German and Italian professional leagues were examined.

Clinical and therapeutic features of myasthenia gravis in adults based on age at onset.

Objective: To describe the characteristics of patients with very-late-onset myasthenia gravis (MG).

Methods: This observational cross-sectional multicenter study was based on information in the neurologist-driven Spanish Registry of Neuromuscular Diseases (NMD-ES). All patients were >18 years of age at onset of MG and onset occurred between 2000 and 2016 in all cases.

Analysis of elite soccer players' performance before and after signing a new contract.

The aim of the current study was to analyse performance differences of football players 2-years prior and the year after signing a new contract (the following year) while taking playing position, nationality, player's role, team ability, and age into account. The sample was comprised of 249 players (n = 109 defenders, n = 113 midfielders; and n = 27 forwards) from four of the major European Leagues (Bundesliga, English FA Premier League, Ligue 1, and La Liga) during the seasons 2008 to 2015. The dependent variables studied were: shooting accuracy, defense (the sum of defensive actions, tackles, blocks, and interceptions), yellow cards, red cards, passing accuracy, tackle success, and minutes played per match.

The virtual patient as a learning tool: a mixed quantitative qualitative study.

Background: The use of simulation in medical education has been widely accepted. There are different types of medical simulators that vary in both accuracy to emulate the real world (fidelity) and cost of development or acquisition. There is significant evidence that supports the use of high-fidelity simulators (i.

Functional evaluation before lung resection: searching for a low technology test in a safer environment for the patient: a pilot study.

Objectives: Stair climbing is considered the first step for functional evaluation of patients requiring anatomical lung resection who have low-predicted postoperative forced expiratory volume in the first second of expiration (FEV1) or diffusing capacity of the lungs for carbon monoxide (DLCO) values. Nevertheless, stair climbing is not performed in many centres because of structural issues or patient safety concerns. We hypothesized that comparable exercise can be obtained on an ergometric bicycle in a safer environment where any adverse event can be treated.

e-Consultation Improves Efficacy in Thoracic Surgery Outpatient Clinics.

Objective: The aim of this study is analysing the impact of the systematic versus occasional videoconferencing discussion of patients with two respiratory referral units along 6 years of time over the efficiency of the in-person outpatient clinics of a thoracic surgery service.

Method: Retrospective and comparative study of the evaluated patients through videoconferencing and in-person first visits during two equivalents periods of time: Group A (occasional discussion of cases) between 2008-2010 and Group B (weekly regular discussion) 2011-2013. Data were obtained from two prospective and electronic data bases.

Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death.

In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action of this hormone during ischemia.

The risk of bilobectomy compared with lobectomy: a retrospective analysis of a series of matched cases and controls.

Objectives: Bilobectomy is considered to be a risky procedure due to space mismatch between the pleural space and the remnant lung. The objective of this study was to evaluate if postoperative complications related or not to size mismatch are more frequent after bilobectomy compared with right lobectomy cases.

Methods: Retrospective case-control study on a series of matched non-small-cell lung cancer patients.

The risk of death due to cardiorespiratory causes increases with time after right pneumonectomy: a propensity score-matched analysis.

Objectives: The study aimed to compare in-hospital, 30-day and non-cancer-related 6-month death rates in a series of right and left pneumonectomy cases matched according to functional parameters.

Methods: A retrospective study was conducted on a series of 263 non-small cell lung cancer patients who underwent pneumonectomy. Left and right pneumonectomy cases were matched according to propensity scores using the following variables: age, coronary artery disease, any other cardiac comorbidity and predicted postoperative forced expiratory volume in the 1st second (ppoFEV1).

Occupational exposure to hepatitis E virus (HEV) in swine workers.

The aim of this work was to study the prevalence of hepatitis E virus (HEV) and the risk factors for the acquisition of the virus in a population in contact with swine and unexposed to swine. A total of 198 individuals, 97 unexposed (49%) and 101 exposed (51%) to swine, were tested for the presence of HEV infection. The prevalence of anti-HEV IgG in the exposed group was 18.

Autochthonous hepatitis E infection in a slaughterhouse worker.

We report the first hepatitis E infection case detected in a slaughterhouse worker. The identified strain belonged to genotype 3, subtype 3f. Partial sequence analysis of the strain isolated from his serum showed a percentage of nucleotide homology ranging from 83.

Detection of hepatitis E virus shedding in feces of pigs at different stages of production using reverse transcription-polymerase chain reaction.

The aim of this study was to determine at which production stages hepatitis E virus (HEV) is shed by the highest number of pigs and to estimate the relative risk associated with each stage. For this purpose, 146 fecal samples of pigs from 21 farms were studied. In addition, 1 sample from the manure ditch and another sample of drinking water, collected directly from the trough located in the pen, were taken from 16 farms.