Publications by authors named "Maria-Jose Sevilla-Sanchez"
The antitumor potential of proteins from snake venoms has been studied in recent decades, and evidence has emerged that phospholipases A can selectively attack cells of various types of tumors. Previous results have shown that phospholipase A ", isolated from snake venom, displayed antitumoral activity on cervical cancer and did not alter the viability of non-tumorigenic cells. However, until now, there was no evidence of its safety at the local and systemic levels, nor had experiments been developed to demonstrate that its production using recombinant technology allows us to obtain a molecule with effects similar to those generated by native phospholipase.
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- In Colombia, snakebites are commonly caused by several snake genera, including Bothrocophias, which can lead to serious health issues like amputations and death.
- A study focused on the venom of Bothrocophias campbelli revealed it has a lethal dose of 142.7 µg/mouse and shows potent myotoxic and edematogenic activities, while its hemorrhagic effects are relatively weaker.
- The venom's effects on muscle tissue include severe damage and inflammation, suggesting that bites may result in significant muscle necrosis and swelling, with potential complications like compartment syndrome.
Article Synopsis
- - Advances in chemotherapy for cervical cancer often harm patients' quality of life, creating a need for safer, natural therapy alternatives.
- - A phospholipase A type-Asp49 from snake venom shows selective toxicity against cervical cancer cell lines (HeLa and Ca Ski) without damaging their membranes.
- - The study concludes that this compound disrupts cell adhesion and affects survival pathways, positioning it as a promising candidate for developing effective cervical cancer treatments.
We report two snakebites by Micrurus ortoni in Colombia and one by M. hemprichii in Perú. In two of the cases, we observed mild to moderate motor neurological involvement and in all patients, there was a marked sensory effect with hyperesthesia and hyperalgesia radiating from the bite site to the entire ipsilateral hemibody.
View Article and Find Full Text PDFIntroduction: Snakebite is a relevant public health problem in Colombia, which is evident in epidemiological data at the Latin American level, where it ranks third place in the number of snakebites, after México and Brazil. Objective: To perform a retrospective analysis of snakebite accidents in the department of Cauca between 2009 and 2018 based on the data from the Public Health Surveillance System of Colombia reported to the Health Institute of Cauca. Materials and methods: We compiled and interpreted the information from the compulsory snakebite notification forms for the study’s 10 years period.
View Article and Find Full Text PDFIntroduction. Snakebite envenoming is a relevant public health problem, and, in Colombia, it was included as a mandatory notification event since 2004. Because it is a tropical country with great ecosystem diversity, it occupies third place in Latin America, after Mexico and Brazil, reaching the highest number of snakebites.
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