Interference of metamizole in the measurement of serum creatinine concentration.

Objectives: There is little literature on the interference of metamizole in measurement creatinine concentration by the enzymatic method. Some studies have postulated that the dipyrone molecule is responsible for interfering in the last reaction of the enzymatic method sequence, due to its similarity with the 4-aminophenazone molecule. The aim of this study is to examine the interference of the presence of metamizole in the measurement of serum creatinine concentration by the enzymatic method.

Handling of lipemic samples in the clinical laboratory.

Interferences in the clinical laboratory may lead physicians misinterpret results for some biological analytes. The most common analytical interferences in the clinical laboratory include hemolysis, icterus and lipemia. Lipemia is defined as turbidity in a sample caused by the accumulation of lipoproteins, mainly very-low density lipoproteins (VLDL) and chylomicrons.

Discrepancies in Lipemia Interference Between Endogenous Lipemic Samples and Smoflipid-Supplemented Samples.

Background: Manufacturers evaluate lipemia-induced interference using Intralipid, but it does not contain all lipoprotein types. The aim of this study was to evaluate lipemiainduced interference in biochemical parameters from endogenous lipemic samples and SMOFlipid supplemented samples, in order to assess if SMOFlipid can be used in lipemic interference studies.

Methods: Serum pools were supplemented with SMOFlipid to achieve 800 mg/dL and 1500 mg/dL triglyceride concentration, and analyzed for 25 biochemical parameters both before and after the supplementation.

Dynamic profiles and predictive values of some biochemical and haematological quantities in COVID-19 inpatients.

Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in some hospitalized patients has shown some important alterations in laboratory tests. The aim of this study was to establish the most relevant quantities associated with the worst prognosis related to COVID-19.

Materials And Methods: This was a descriptive, longitudinal, observational and retrospective study, in a cohort of 845 adult inpatients from Bellvitge University Hospital (L'Hospitalet de Llobregat, Barcelona, Spain).

Estimation of change limits (deltacheck) in clinical laboratory.

Objectives: Change limits, more commonly called delta check, are those in which a change in a patient's measured result in relation to their corresponding preceding measurement is suspected of being erroneous and should be considered as a doubtful result. The aim of this study was to provide change limits for some biochemical and haematological quantities to detect doubtful measured results and to assess its effectiveness to detect erroneous results for their application in and the standardization of the plausibility control.

Methods: Change limits have been estimated for 13 biochemical and 6 haematological quantities.

Analysis of laboratory critical values at a referral Spanish tertiary university hospital.

Introduction: The aim of this study was to analyse critical value data from our laboratory and compare our critical value reporting policy with others in the literature.

Materials And Methods: Analysis of critical values was performed on data obtained over a 6-month period in a tertiary university hospital.

Results: We identified 5723 critical values, of which approximately 80% came from STAT testing (4577), 15% from routine inpatients testing (884) and 5% from routine outpatients testing (262).

Removing Lipemia in Serum/Plasma Samples: A Multicenter Study.

Background: Lipemia, a significant source of analytical errors in clinical laboratory settings, should be removed prior to measuring biochemical parameters. We investigated whether lipemia in serum/plasma samples can be removed using a method that is easier and more practicable than ultracentrifugation, the current reference method.

Methods: Seven hospital laboratories in Spain participated in this study.

Estimation of Alert and Change Limits of Haematological Quantities and its Application in the Plausibility Control.

Introduction: In the process of quality assurance of the measured values of the clinical laboratory, one of the purposes is to perform the validation of patients' measured values in the most objective way. This validation process is called plausibility control which may be defined as the set of procedures used to decide if a patient's measured value is valid according to established clinical and biological criteria. The aim of this study is to propose a model to estimate alert and change limits of measured values of the blood cell count, to be applied to detect doubtful patients' measured values.