[Anorexia nervosa in a worker: a case report].

We describe the management of a case of anorexia nervosa (body mass index, -BMI-, 13,6 Kg/m2) in a bank teller. The case was detected through routine occupational health surveillance. After being evaluated by different specialists (general practitioner, psychiatrist and endocrinologist) and being closely monitored (by psychology, nursing, and occupational medicine), the worker regained weight to a near normal BMI (17 Kg/m2) in less than a year and a half.

Case-control study of semicircular lipoatrophy, a new occupational disease in office workers.

Objectives: Semicircular lipoatrophy (SL) is an emerging occupational pathology. Its etiology is poorly understood. We intend to establish the probable risk factors and estimate the relative risk.

Familial porphyria cutanea tarda in Spain: characterization of eight novel mutations in the UROD gene and haplotype analysis of the common p.G281E mutation.

Porphyria cutanea tarda (PCT) results from decreased activity of uroporphyrinogen decarboxylase (UROD) in the liver. Deficiency in this enzyme results in accumulation of highly carboxylated porphyrins responsible for the disease. PCT usually occurs in adulthood and is characterized by cutaneous photosensitivity, hyperpigmentation, skin fragility and hypertrichosis.

Smoking but not homozygosity for CYP1A2 g-163A allelic variant leads to earlier disease onset in patients with sporadic porphyria cutanea tarda.

Porphyria cutanea tarda (PCT) results from decreased activity of hepatic uroporphyrinogen decarboxylase (UROD). Both sporadic and familial forms are characterised by typical cutaneous lesions triggered by genetic/environmental factors. Studies in rodents showed that cytochrome P4501A2 (CYP1A2) plays a central role in the synthesis of a competitive inhibitor of hepatic UROD, but there is little evidence in humans.