Publications by authors named "Maria-Bianca Mititelu"
Article Synopsis
- NAD (Nicotinamide adenine dinucleotide) is essential for cellular metabolism and acts as an RNA cap, but its role in this function is not fully understood.
- Research on HIV-1-infected cells showed that certain small nuclear and nucleolar RNAs lost their NAD cap, which could affect their stability.
- By increasing the enzyme that removes the NAD cap, researchers found that HIV-1 infectivity increased, indicating that NAD capping might hinder the virus's ability to replicate.
Diadenosine Tetraphosphate (Ap A) Serves as a 5' RNA Cap in Mammalian Cells.
Angew Chem Int Ed Engl
February 2024
The recent expansion of the field of RNA chemical modifications has changed our understanding of post-transcriptional gene regulation. Apart from internal nucleobase modifications, 7-methylguanosine was long thought to be the only eukaryotic RNA cap. However, the discovery of non-canonical RNA caps in eukaryotes revealed a new niche of previously undetected RNA chemical modifications.
View Article and Find Full Text PDFRecent discoveries of various noncanonical RNA caps, such as dinucleoside polyphosphates (Np N), coenzyme A (CoA), and nicotinamide adenine dinucleotide (NAD) in all domains of life have led to a revision of views on RNA cap function and metabolism. Enzymes from the NudiX family capable of hydrolyzing a polyphosphate backbone attached to a nucleoside are the strongest candidates for degradation of noncanonically capped RNA. The model plant organism encodes as many as 28 NudiX enzymes.
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