Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural Tanzania.

Objectives: To quantify the association between prevalent or incident Herpes simplex virus type-2 (HSV2) infection and the incidence of HIV seroconversion among adults in the general population in rural Tanzania.

Study Population: Adults aged 15-54 years sampled randomly from 12 rural communities in Mwanza Region, Tanzania and recruited to a randomized trial of improved treatment of sexually transmitted diseases.

Study Design: Unmatched case-control study nested within trial cohort.