Publications by authors named "Maria de Los Reyes Jimenez-Leon"
Cell Mol Immunol
September 2021
Article Synopsis
- SARS-CoV-2 infection leads to heightened inflammation primarily due to dysregulated dendritic cell (DC) activity, particularly affecting the immune response.
- Dendritic cells, especially plasmacytoid DCs, are crucial for antiviral defense as they produce interferon-alpha (IFN-α), which is notably deficient in COVID-19 patients and correlates with severe disease outcomes.
- Research shows that both hospitalized and nonhospitalized patients have persistent reductions in specific DC subsets even months after infection, indicating potential long-term effects on the immune system.
