Sex-dependent effect of aging on calcium signaling and expression of TRPM2 and CRAC channels in human neutrophils.

The vulnerability of older adults to bacterial infections has been associated with age-related changes in neutrophils. We analyzed the consequences of aging on calcium (Ca) mobilization and TRPM2 and CRAC channels expression in human neutrophils. The percentages of granulocytes, mature neutrophils, and neutrophil precursors were equivalent between young and older adults.

Aging does not affect calcium response to CCL2 and LPS in human monocytes.

Monocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca) response to CCL2 and LPS in human monocytes.