Oligodendrocyte-specific expression of - suggests a role in myelination with prognostic value in oligodendroglioma.

The segmentally duplicated Pregnancy-specific glycoprotein () locus on chromosome 19q13 may be one of the most rapidly evolving in the human genome. It comprises ten coding genes () and one predominantly non-coding gene () that are expressed in the placenta and gut, in addition to several poorly characterized long non-coding RNAs. We report that long non-coding RNA has an oligodendrocyte-specific expression pattern and is co-expressed with genes encoding key myelin constituents.

JRK binds satellite III DNA and is necessary for the heat shock response.

JRK is a DNA-binding protein of the pogo superfamily of transposons, which includes the well-known centromere binding protein B (CENP-B). Jrk null mice exhibit epilepsy, and growth and reproductive disorders, consistent with its relatively high expression in the brain and reproductive tissues. Human JRK DNA variants and gene expression levels are implicated in cancers and neuropsychiatric disorders.