Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate.

Purpose: To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats.

Methods: A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not receive any medication.