[Genetic polymorphisms of low molecular weight protein tyrosine phosphatase (LMW-PTP): relationship with erythrocyte enzymatic phenotype in patients with Systemic Lupus Erythematosus].

Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disease characterized by the loss of self-tolerance revealing defective immune regulatory mechanisms. ACP1 is a highly polymorphic erythrocyte LMW-PTP isozyme encoded by a gene presenting three alleles (A B C). These alleles determine different fast slow isozyme proportions having distinct cellular localization and biological functions.