Publications by authors named "Maria da Gloria Aureliano Melo Cavalcanti"
Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Diego José Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gonçales Ana Karine Araújo Soares Maria da Gloria Aureliano Melo Cavalcanti
Immunobiology
January 2022
Article Synopsis
- Soluble TNF receptors (sTNFR1 and sTNFR2) inhibit TNF and their levels are elevated in various diseases, including Chagas disease, where TNF plays a crucial role in immune response and pathology.
- In a study of 132 chronic Chagas disease patients, it was found that levels of sTNFR1 and sTNFR2 were higher in infected individuals compared to non-infected controls, indicating they may help regulate TNF activity.
- A moderate correlation was observed between sTNFR1 and TNF in patients with the indeterminate form of the disease, suggesting a protective mechanism against progression to more severe conditions like heart disease.
Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens.
Suellen Carvalho de Moura Braz Virginia Maria Barros de Lorena Adriene Siqueira Melo Maria da Glória Aureliano Melo Cavalcanti Yara de Miranda Gomes
Rev Soc Bras Med Trop
January 2014
Introduction: CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease.
Methods: Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for lymphocytes at distinct time points.