Publications by authors named "Maria da Gloria Aureliano Melo Cavalcante"
Vitamin D treatment distinctly modulates cytokine production by peripheral blood mononuclear cells among patients with chronic cardiac and indeterminate clinical forms of Chagas disease.
Kamila Kássia Dos Santos Oliveira Diego José Lira Torres Michelle da Silva Barros Leyllane Rafael Moreira Claudeir Dias da Silva Junior Maria da Glória Aureliano Melo Cavalcante
Immun Inflamm Dis
September 2024
Article Synopsis
- Chagas disease, caused by Trypanosoma cruzi, has acute and chronic phases, with chronic Chagas cardiomyopathy being the most notable, and there's a potential link between vitamin D deficiency and cardiovascular issues.
- The study aimed to assess the effects of vitamin D on blood cells from patients with various chronic forms of Chagas disease by measuring cytokine production in vitro.
- Results indicated that vitamin D treatment influenced cytokine production, showing distinct changes among patients, though no statistically significant differences were found among the groups.
TNF blockers alone and associated with Benznidazole impact in vitro cytokine dynamics in chronic Chagas disease.
Diego José Lira Torres Kamila Kássia Dos Santos Oliveira Michelle da Silva Barros Leyllane Rafael Moreira Luciane de Freitas Firmino Maria da Glória Aureliano Melo Cavalcante
Parasite Immunol
February 2024
Article Synopsis
- Studies on the immune response in Chagas disease show that symptomatic patients, especially those with severe Chagas heart disease, have an inflammatory immune profile dominated by tumour necrosis factor (TNF).
- The research evaluates cytokine levels in patients with different clinical forms of Chagas disease after treatment with TNF blockers (Adalimumab and Etanercept) and benznidazole, measuring the effects on both regulatory and inflammatory cytokines.
- Results indicate that Adalimumab was more effective in blocking TNF, while Etanercept showed a specific decrease in TNF levels only in the most severe cases, suggesting that targeting TNF could be a beneficial strategy for the immunological treatment of severe Chagas heart disease.