Sleep and circadian rhythm alterations in myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID fatigue syndrome and its association with cardiovascular risk factors: A prospective cohort study.

This study aimed to investigate circadian rhythm manifestations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients (including a subpopulation of long-COVID patients) and matched healthy controls while also exploring their association with cardiovascular health variables. Thirty-one ME/CFS patients (75% females), 23 individuals diagnosed with post-COVID ME/CFS (56% females) and 31 matched healthy controls (68% females) were enrolled in this study. Demographic and clinical characteristics were assessed using validated self-reported outcome measures.

The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: study in the horse.

The effectiveness and safety of allogeneic mesenchymal stem/stromal cells (MSCs) can be affected by patient's immune recognition. Thus, MSC immunogenicity and their immunomodulatory properties are crucial aspects for therapy. Immune responses after allogeneic MSC administration have been reported in different species, including equine.

Integrated Building Modelling Using Geomatics and GPR Techniques for Cultural Heritage Preservation: A Case Study of the Charles V Pavilion in Seville (Spain).

This paper highlights the fundamental role of integrating different geomatics and geophysical imaging technologies in understanding and preserving cultural heritage, with a focus on the Pavilion of Charles V in Seville (Spain). Using a terrestrial laser scanner, global navigation satellite system, and ground-penetrating radar, we constructed a building information modelling (BIM) system to derive comprehensive decision-making models to preserve this historical asset. These models enable the generation of virtual reconstructions, encompassing not only the building but also its subsurface, distributable as augmented reality or virtual reality online.

Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study.

Background: Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers and illness severity in these conditions.

Methods: This single-site, prospective, cross-sectional, pilot cohort study aimed to distinguish between the two patient populations by using self-reported outcome measures and circulating biomarkers of endothelial function and systemic inflammation status.

Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation.

There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test and analysis of the peripheral skin temperature variations and vascular endothelium state in ME/CFS patients. Sixty-seven adult female ME/CFS patients and 48 healthy controls were enrolled.

Can suggestions of non-occurrence lead to claims that witnessed events did not happen?

In three experiments, we examined whether general suggestions of non-occurrence -suggestions that experienced events did not occur- would lead participants to claim that events they witnessed never happened. Participants viewed a video depicting the investigation of a child kidnapping case and subsequently were exposed to suggestions of non-occurrence either once (Experiments 1 and 3) or three times (Experiments 2 and 3). The results provided no evidence that single suggestions of non-occurrence influenced participants' memories or belief (Experiments 1 and 3).

Correcting eyewitness suggestibility: does explanatory role predict resistance to correction?

Many studies have documented that exposure to post event misinformation can lead eyewitnesses to misremember witnessing events they did not see and do so with high confidence. The goal of the present study was to investigate whether reporting of suggested misinformation can be reversed following a correction, and if so, whether misinformation would be more resistant to correction when it serves an explanatory function than when it does not. In two experiments participants witnessed an event, were exposed to a blatantly false suggestion(s) and one week later received a correction followed by a test of their memory for the witnessed event.

Does evaluating belief prior to its retraction influence the efficacy of later corrections?

News stories unfold over time, with initial reports sometimes containing mistaken accounts of the newsworthy outcome that are ultimately revised or corrected. Because facts associated with newsworthy events are accumulated in this piecemeal fashion, readers often have repeated opportunities to reflect upon, discuss, and evaluate their belief in these accounts before they learn that initial news reports have been revised or retracted. The primary goal of the present study was to assess whether rating the strength of one's belief in the initially reported, mistaken cause might influence the efficacy of a later correction.

Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis.

Background: Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME.

Unemployment and work disability in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a community-based cross-sectional study from Spain.

Background: Few reports have examined the association between unemployment and work disability in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). This study explored the key determinants of work disability in a CFS/ME cohort.

Methods: A community-based prospective study included 1086 CFS/ME patients aged 18-65 years.

Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Background: Several studies have suggested that low levels of omega-3 fatty acids (n-3 PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with cardiovascular risk, major depression, sleep problems, inflammation and other health-related issues. So far, however, erythrocyte PUFA status in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) has not been established. This study aimed to determine whether n-3 PUFA content and omega-3 index are associated with measures in CFS/ME patients.

Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients frequently show autonomic symptoms which may be associated with a hypothalamic dysfunction. This study aimed to explore circadian rhythm patterns in rest and activity and distal skin temperature (DST) and their association with self-reported outcome measures, in CFS/ME patients and healthy controls at two different times of year. Ten women who met both the 1994 CDC/Fukuda definition and 2003 Canadian criteria for CFS/ME were included in the study, along with ten healthy controls matched for age, sex and body mass index.

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort.

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study.

Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) is an acquired, complex and multisystem condition of unknown etiology, no established diagnostic lab tests and no universally FDA-approved drugs for treatment. CFS/ME is characterised by unexplicable disabling fatigue and is often also associated with numerous core symptoms. A growing body of evidence suggests that extracellular vesicles (EVs) play a role in cell-to-cell communication, and are involved in both physiological and pathological processes.

Generation of a serum free CHO DG44 cell line stably producing a broadly protective anti-influenza virus monoclonal antibody.

Because of the broad neutralization and in vivo protection across influenza A and influenza B virus strains, monoclonal antibody CR9114 is widely used in influenza virus research as a positive control in many experiments. To produce amounts sufficient for the demand requires regular transient transfections, resulting in varying yield as well as differing batch to batch quality. Here, we report the development of a serum-free CHO DG44 cell line, stably producing a CR9114-like antibody with a potential to become a useful influenza virus research tool.

Mechanisms of eyewitness suggestibility: tests of the explanatory role hypothesis.

In a recent paper, Chrobak and Zaragoza (Journal of Experimental Psychology: General, 142(3), 827-844, 2013) proposed the explanatory role hypothesis, which posits that the likelihood of developing false memories for post-event suggestions is a function of the explanatory function the suggestion serves. In support of this hypothesis, they provided evidence that participant-witnesses were especially likely to develop false memories for their forced fabrications when their fabrications helped to explain outcomes they had witnessed. In three experiments, we test the generality of the explanatory role hypothesis as a mechanism of eyewitness suggestibility by assessing whether this hypothesis can predict suggestibility errors in (a) situations where the post-event suggestions are provided by the experimenter (as opposed to fabricated by the participant), and (b) across a variety of memory measures and measures of recollective experience.

Analyzing Confabulations in Schizophrenia and Healthy Participants.

Objectives: Confabulations occur in schizophrenia and certain severe neuropsychiatric conditions, and to a lesser degree in healthy individuals. The present study used a forced confabulation paradigm to assess differences in confabulation between schizophrenia patients and healthy controls.

Methods: Schizophrenia patients (n=60) and healthy control participants (n=19) were shown a video with missing segments, asked to fill in the gaps with speculations, and tested on their memory for the story.

Belief in corrective feedback for common misconceptions: Implications for knowledge revision.

When correcting a common misconception, it seems likely that for corrective feedback to be effective, it needs to be believed. In 2 experiments, we assessed how participants' belief in the validity of corrective feedback regarding individual misconceptions influenced knowledge revision. After responding about the validity of a set of misconceptions, participants received either a refutation alone (feedback that they were correct or incorrect) or a refutation accompanied by a supporting explanation, and then rated their belief in the corrective feedback.

Does reactivating a witnessed memory increase its susceptibility to impairment by subsequent misinformation?

In a recent article, Chan and LaPaglia (2013) provided arguments and evidence to support the claim that reactivating a witnessed memory (by taking a test) renders the memory labile and susceptible to impairment by subsequent misinformation. In the current article, we argue that Chan and LaPaglia’s (2013) findings are open to alternative interpretations, and further test the hypothesis that reactivation increases a witnessed memory’s susceptibility to impairment. To this end, the current studies used a different set of materials and a different measure of memory impairment, the Modified Recognition Test (McCloskey & Zaragoza, 1985).

The Impact of Multifaceted Questions on Eyewitness Accuracy Following Forced Fabrication Interviews.

Lawyers will frequently use complex-question forms, such as multifaceted questions (single questions that contain both a true and a false proposition), when cross-examining witnesses, and prior research has shown that use of such questions reduces testimonial accuracy. The present study extends this research by using a forced fabrication paradigm (Chrobak & Zaragoza, 2008) to assess how multifaceted questions might affect eyewitness suggestibility after exposure to misleading post-event information. Consistent with prior studies, the use of multifaceted questions led to lower accuracy than simple questions.

The continued influence of implied and explicitly stated misinformation in news reports.

The piecemeal reporting of unfolding news events can lead to the reporting of mistaken information (or misinformation) about the cause of the newsworthy event, which later needs to be corrected. Studies of the continued influence effect have shown, however, that corrections are not entirely effective in reversing the effects of initial misinformation. Instead, participants continue to rely on the discredited misinformation when asked to draw inferences and make judgments about the news story.

Health research funding in Mexico: the need for a long-term agenda.

Background: The legal framework and funding mechanisms of the national health research system were recently reformed in Mexico. A study of the resource allocation for health research is still missing. We identified the health research areas funded by the National Council on Science and Technology (CONACYT) and examined whether research funding has been aligned to national health problems.

When forced fabrications become truth: causal explanations and false memory development.

Studies of text comprehension have amply demonstrated that when reading a story, people seek to identify the causal and motivational forces that drive the interactions of characters and link events (e.g., Zwaan, Langston, & Graesser, 1995), thereby achieving explanatory coherence.

False Memories for Suggestions: The Impact of Conceptual Elaboration.

Relatively little attention has been paid to the potential role that reflecting on the meaning and implications of suggested events (i.e., conceptual elaboration) might play in promoting the creation of false memories.

A fish-oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice.

Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo.