Midline Catheters as an Alternative for Central Venous Catheters in Venous Oxygen Saturation Monitoring: A Single Center Experience.

Background: Central venous oxygen saturation (ScvO2) obtained from a central venous catheter (CVC) is often used to approximate oxygen delivery in critically ill patients. Despite their importance in administering medications and monitoring oxygen delivery, the use of CVCs can be associated with significant complications. Midline catheters are inserted via a peripheral vein above the antecubital fossa and provide a safe alternative to CVCs.

Technical Update No. 433: eHealth Solutions for Urinary Incontinence Among Women.

Objective: The purpose of this technical update is to establish the state of the science regarding emerging and novel electronic health (eHealth) and mobile health (mHealth) solutions for urinary incontinence among women.

Target Population: Women over 18 years with urinary incontinence.

Options: Websites and mobile health applications are useful in the conservative care of urinary incontinence.

Directive clinique n 397 - Prise en charge conservatrice de l'incontinence urinaire chez les femmes.

Objectif: Exposer les données probantes relatives à la prise en charge conservatrice, y compris les options d'évaluation et de traitement, de l'incontinence urinaire chez les femmes. UTILISATEURS CONCERNéS: Les fournisseurs de soins de première ligne et les professionnels de la santé spécialisés, y compris, mais sans s'y limiter, les médecins, les infirmières, les sages-femmes et les physiothérapeutes en santé périnéale.

Population Cible: Les femmes (> 18 ans) atteintes d'incontinence urinaire.

No. 397 - Conservative Care of Urinary Incontinence in Women.

Objective: To outline the evidence for conservative care, including both assessment and management options, for urinary incontinence in women.

Intended Users: Relevant primary care providers and medical specialists including but not limited to physicians, nurses, midwives, and pelvic health physiotherapists.

Target Population: Women (>18 years of age) with urinary incontinence.

Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α.

There is a vast gulf between the two primary strategies for simulating protein-ligand interactions. Docking methods significantly limit or eliminate protein flexibility to gain great speed at the price of uncontrolled inaccuracy, whereas fully flexible atomistic molecular dynamics simulations are expensive and often suffer from limited sampling. We have developed a flexible docking approach geared especially for highly flexible or poorly resolved targets based on mixed-resolution Monte Carlo (MRMC), which is intended to offer a balance among speed, protein flexibility, and sampling power.

Association between intrapartum epidural use and maternal postpartum depression presenting for medical care: a population-based, matched cohort study.

Purpose: To evaluate whether intrapartum epidural use is associated with maternal postpartum depression presenting for medical care.

Methods: Population-based, matched cohort study including all adult nulliparous women in Ontario, Canada from 2006 to 2012 without a history of depression, who had a term vaginal delivery. Seventy covariates including maternal demographics, medical and psychiatric conditions, prenatal and perinatal complications, and healthcare utilization were measured.

Robotic-assisted vesicovaginal fistula repair using an extravesical approach without interposition grafting.

Background: Post-hysterectomy vesicovaginal fistula (VVF) is rare. In addition to conventional abdominal and vaginal approaches, robotic-assisted VVF repairs have recently been described. We present a case of an extravesical, robotic-assisted VVF repair, without placement of an interposition graft performed in a Canadian teaching center.

C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division.

All 302 neurons in the C. elegans hermaphrodite arise through asymmetric division of neuroblasts. During embryogenesis, the C.

Dissecting the function of a protruding loop in AcrB trimerization.

The resistance-nodulation-cell division family multidrug transporter Acriflavine resistance protein B (AcrB) from Eschericha coli is an obligate homotrimer. Approximately, 45% of the inter-subunit interface is contributed by a protruding loop (also referred to as the thumb) and its corresponding binding tunnel in the neighboring subunit. In an earlier study, we have demonstrated that a single Pro to Gly mutation in the loop drastically destabilized AcrB trimer and reduced its substrate efflux activity.