Publications by authors named "Maria Vitoria Assumpcao Mourao"
MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis.
Front Immunol
August 2024
Article Synopsis
- - Visceral leishmaniasis (VL) is a significant neglected tropical disease where the interaction between immune cells and the parasite is key in determining infection and immune response; type-1 T-cells promote inflammation, while type-2 T-cells support infection establishment.
- - Recent research highlights the role of mucosal-associated invariant T (MAIT) cells in VL, showing that they can produce essential inflammatory cytokines upon activation, impacting the immune response to the disease.
- - Findings indicate that VL patients exhibit more activated neutrophils than non-infected individuals, and blocking MR1 can reduce critical inflammatory markers and shift cytokine production towards a detrimental type-2 response, suggesting MR1 involvement in protective immunity against infection.
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of , is limited. This study showed that in response to , human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner.
View Article and Find Full Text PDFClinical and laboratory risk factors for death from visceral leishmaniasis (VL) are relatively known, but quantitative real-time polymerase chain reaction (qPCR) might assess the role of parasite load in determining clinical outcome. The aim of this study was to identify risk factors, including parasite load in peripheral blood, for VL poor outcome among children. This prospective cohort study evaluated children aged ≤ 12 years old with VL diagnosis at three times: pre-treatment (T0), during treatment (T1) and post-treatment (T2).
View Article and Find Full Text PDFIntroduction: Rapid diagnostic tests (RDTs) may improve the early detection of visceral leishmaniasis (VL), but their real-world performance requires additional study. Therefore, we evaluated the performance of an rK39-based RDT (Kalazar Detect™) for the detection of VL in an endemic, large urban area.
Methods: Data were collected from a registry of rK39 RDT performed at 11 emergency care units in Belo Horizonte, Brazil, and from a national database of reportable communicable diseases of the Sistema de Informação de Agravos de Notificação (SINAN).
[Notification of healthcare associated infections based on international criteria performed in a reference neonatal progressive care unity in Belo Horizonte, MG].
Rev Bras Epidemiol
March 2013
Objective: To describe occurrence of Healthcare Related Infections in a neonatal unit of public reference service in Belo Horizonte-MG, based on international criteria.
Methods: This is a descriptive study, performed by active searching, in the Progressive Care Unit Neonatal Hospital das Clinicas, Federal University of Minas Gerais (HC / UFMG), from 2008 to 2009. Notification of infections was based on National Healthcare Safety Network (NHSN) criteria.