Publications by authors named "Maria Victoria Heggenhougen"
Article Synopsis
- Antibiotic resistance is a significant issue for treating staphylococcal infections, prompting the need for new strategies to enhance antibiotic effectiveness.
- The study developed a CRISPR interference library to pinpoint genes influencing antibiotic susceptibility, particularly targeting the antibiotic dalbavancin, and identified both known and previously unrecognized genes involved in antibiotic tolerance.
- Findings suggest that certain gene knockdowns, like KapB, can specifically increase sensitivity to dalbavancin, offering insights that could lead to novel antimicrobial treatments.
In oval-shaped , septal and longitudinal peptidoglycan syntheses are performed by independent functional complexes: the divisome and the elongasome. Penicillin-binding proteins (PBPs) were long considered the key peptidoglycan-synthesizing enzymes in these complexes. Among these were the bifunctional class A PBPs, which are both glycosyltransferases and transpeptidases, and monofunctional class B PBPs with only transpeptidase activity.
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