Midazolam induced cerebral cortex changes in 30-day-old mice treated from 8 to 29 days of age.

The exposure of 8 to 29-day-old mouse pups to midazolam (MDZ) produces the same type of histological alterations in the cerebral cortex as those caused in mice by exposure in utero to diazepam (DZ) from day 6 to 17 of gestation. Two groups of 10 each ICR (Harlan Mexico) strain male mice were injected: the first with a single daily MDZ dose (2.0 mg/kg/bw, s.

Midazolam administered to 8-day-old mouse pups for three weeks induces cerebellar cortex alterations.

Midazolam (MDZ) administered during the neonatal period induces histological changes in the cerebellar cortex of mouse pups. We investigated whether these changes are similar to those induced by prenatal exposure to diazepam (DZ). Two neonatal ICR-strain mouse groups were injected daily from day 8 to 29.

Motor response of 14-month-old female mice exposed to diazepam prenatally.

The response of adult female mice to diazepam (DZ) can be sculpted by the prenatal experience with the drug. Experiments were performed in ICR strain (Harlan México) mice exposed in utero to DZ. They were born from dams injected (s.