Publications by authors named "Maria V Zeid-Kilani"
J Biol Chem
February 2015
Article Synopsis
- TLR2 and TLR4 are critical components of the innate immune system that recognize microbes and activate immune responses through various signaling pathways involving adaptors like MyD88 and MAL.
- New findings reveal that the adaptors TRAM and TRIF play a significant role in regulating TLR2 signaling, particularly in the induction of the chemokine Ccl5.
- The study suggests that TLR2 signaling may occur from early endosomes and that TRAM and TRIF are essential for effective Ccl5 release and induction of other immune factors, expanding our understanding of TLR2-mediated immune responses.
