Publications by authors named "Maria V Cossu"

Objectives: We compared the effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF) and dolutegravir plus lamivudine (DTG + 3TC) in our cohort of treatment-naive people with HIV (PWH).

Methods: In a multicentre cohort of treatment-naive PWH starting a first-line regimen with either dolutegravir plus lamivudine or BIC/FTC/TAF, Kaplan-Meier survival analysis was used to estimate time to virological failure (VF) and time to treatment discontinuation (TD), whereas Cox regression was used to evaluate predictors of VF and TD. Changes in CD4+ cell count were assessed via non-parametric tests, and linear regression analyses were performed to explore predictors of CD4+ cell count changes.

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The association between human papillomavirus (HPV) and other sexually transmitted infections (STIs) in anal lesions still remains unclear. Aim of the study was to evaluate the prevalence of simultaneous infection of HPV and Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis in individuals screened for HPV anal infection. A total of 507 anal samples were tested for both anal HPV and STIs: 16% resulted positive for one or more non-HPV STIs.

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Objective: Large inter-individual variability in the pharmacokinetics of rilpivirine and cabotegravir has been reported in the first weeks after starting long-acting injectable (LAI) therapy. Here, we assessed the distribution of rilpivirine and cabotegravir trough concentrations in people with HIV (PWH) on long-term LAI treatment.

Methods: Adult PWH treated with LAI for at least 32 weeks with an assessment of drug plasma trough concentrations were considered.

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Objective: To define macro symptoms of long COVID and to identify predictive factors, with the aim of preventing the development of the long COVID syndrome.

Design: A single-centre longitudinal prospective cohort study conducted from May 2020 to October 2022.

Setting: The study was conducted at Luigi Sacco University Hospital in Milan (Italy).

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Article Synopsis
  • The study investigates the prevalence of oral HPV types among patients with symptoms of oral and upper respiratory tract lesions in a Milan hospital from 2019 to 2022, focusing on those with known risk factors for HPV infection.
  • A total of 110 patients were analyzed, with 12.7% testing positive for HPV DNA; out of these, 3.6% had high-risk (HR) HPV types and 9.1% had low-risk (LR) types, with HPV 16 and 6 being the most common.
  • The findings suggest a link between HPV and head and neck cancers, highlighting the need for HPV testing in symptomatic individuals and advocating for improved vaccination rates.
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Article Synopsis
  • HPV is the most common sexually transmitted infection and is notably linked to anal cancer, particularly with HPV 16 being a significant cause of such cases.
  • A study conducted in Italy from 2018 to 2022 tested anal specimens from at-risk individuals, finding that 84% of the 1514 samples were positive for HPV, with high-risk types consistently present over the years.
  • The results highlight a persistent prevalence of oncogenic HPV types, especially among men over 45, emphasizing the need for better HPV screening guidelines and increased vaccination efforts.
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Article Synopsis
  • The GRAd-COV2 vaccine, developed from a gorilla adenovirus, aims to enhance COVID-19 immunity with a focus on a stable spike protein.
  • In a phase 2 trial with 917 participants, the vaccine demonstrated good safety and strong immune responses, especially after a second dose.
  • The vaccine effectively generated a robust T cell response, particularly CD8 T cells, suggesting its potential for future genetic vaccine development in combating variants of concern.
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In 2022, many monkeypox (MPX) outbreaks have been documented in countries where MPX was not endemic. It spread all around the world, especially in European Union and United States. While MPX is classically considered to be transmitted through close contact with lesions, the hypothesis of sexual transmission has been proposed.

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Anal and urethral samples from confirmed cases of monkeypox were screened for monkeypox virus (MPXV) by real-time PCR. Isolation of the virus was subsequently attempted in cell culture. Actively-replicating virus was demonstrated in 13 of 18 and 11 of 15 PCR-positive anal and urethral swabs, respectively, collected within 7 days from symptoms onset.

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Vaccination toward SARS-CoV-2 reduced mortality and 'boosters' are being implemented. We offer scientific contribution about IgG production in the COVID-19 experienced population. From January 2021 to March 2021, 183 residents and staff from the Elderly Nursing Home "San Giuseppe Moscati" who had received two doses of the BNT162b2 vaccine were enrolled.

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