The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung.

An antibody panel is needed to definitively differentiate between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in order to meet more stringent requirements for the histologic classification of lung cancers. Staining of desmosomal plaque-related proteins may be useful in the diagnosis of lung SCC. We compared the usefulness of six conventional (CK5/6, p40, p63, CK7, TTF1, and Napsin A) and three novel (PKP1, KRT15, and DSG3) markers to distinguish between lung SCC and AC in 85 small biopsy specimens (41 ACs and 44 SCCs).

Progressive changes in composition of lymphocytes in lung tissues from patients with non-small-cell lung cancer.

Immune cell infiltration is a common feature of many human solid tumors. Innate and adaptative immune systems contribute to tumor immunosurveillance. We investigated whether tumors evade immune surveillance by inducing states of tolerance and/or through the inability of some immune subpopulations to effectively penetrate tumor nests.

[Breastfeeding and its influence into the cognitive process of Spanish school-children (6 years old), measured by the Wechsler Intelligence Scale].

Some scientific evidence support that a better cognitive development during the school age is related with breastfeeding. In this study, the potential benefit of breastfeeding duration is evaluated, related to Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed. A total of 103 children, first year of Primary School, six-year-old, (47 boys and 56 girls), were included from different schools in the province of Granada (Spain) at urban, semi-urban and rural areas.

Differential immunohistochemical localization of desmosomal plaque-related proteins in non-small-cell lung cancer.

Aims: Immunohistochemistry is a highly valuable and widely used tool in the subtyping of lung carcinomas. The aim of this study was to identify markers for the differential diagnosis of non-small-cell carcinomas.

Methods And Results: We report on the immunohistochemical localization of plakophilin-1 (PKP1), keratin-15 (KRT15) and desmoglein-3 (DSG3) intercellular adhesion proteins in samples from 75 primary non-small-cell lung cancers in non-treated patients.

[Statistical analysis of the consumption of nutritional and dietary supplements in gyms].

The abuse of all types of substance to improve sport performance and physical fitness has spread to regularly gym users. The aim of this study was to evaluate the intake of nutritional and dietary supplements in a group of 415 individuals (260 males and 155 females) from 4 gyms in Seville (Spain). The users completed a previously designed questionnaire whose content validity had been tested in a pilot study.

[Comparative study between auditory steady-state responses, auditory brain-stem responses and liminar tonal audiometry].

Objectives: Auditory steady-state responses (ASSR) using frequencies of modulation between 70-110 Hz are a new auditive exploration technique. The aim of the study was to evaluate the contribution of the ASSR to diagnostic of the audition.

Material And Method: Different aportations of auditory steady-states responses (ASSR) and auditory brain-stem responses (ABR) to diagnostic of threshold of audition were studied Differences between these thresholds and thresholds obtained by liminar tonal audiometry (LTA) were studied too.