Publications by authors named "Maria Teresa Mata-Gonzalez"
Article Synopsis
- vNAR antibodies are unique antibodies from sharks that are appealing to biotech and pharma due to their size and ability to penetrate tissues.
- Some existing anti-angiogenic treatments for eye conditions involve discomfort and infection risk from injections, but this study develops a specific vNAR, V13, that targets and neutralizes VEGF effectively in lab models.
- The research shows that V13 can be applied topically and still penetrate the eye, suggesting it could be a promising new treatment for vascular-related eye diseases.
Background: In sepsis, tumor necrosis factor (TNF) is the key factor triggering respiratory burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal antibodies or F(ab')₂ fragments have been used in sepsis with contradictory results. Immunoglobulin new antigen receptors (IgNAR) are a unique subset of antibodies consisting of five constant (CNAR) and one variable domains (VNAR).
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