Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate.

Purpose: Preclinical studies using a new treatment modality called FLASH Radiotherapy (FLASH-RT) need a two-phase procedure to ensure minimal uncertainties in the delivered dose. The first phase requires a new investigation of the reference dosimetry lying outside the conventional metrology framework from national metrology institutes but necessary to obtain traceability, repeatability, and stability of irradiations. The second consists of performing special quality assurance procedure prior to irradiation.

High dose-per-pulse electron beam dosimetry: Commissioning of the Oriatron eRT6 prototype linear accelerator for preclinical use.

Purpose: The Oriatron eRT6 is an experimental high dose-per-pulse linear accelerator (linac) which was designed to deliver an electron beam with variable dose-rates, ranging from a few Gy/min up to hundreds of Gy/s. It was built to study the radiobiological effects of high dose-per-pulse/dose-rate electron beam irradiation, in the context of preclinical and cognitive studies. In this work, we report on the commissioning and beam monitoring of the Oriatron eRT6 prototype linac.

High dose-per-pulse electron beam dosimetry: Usability and dose-rate independence of EBT3 Gafchromic films.

Purpose: The aim of this study was to assess the suitability of Gafchromic EBT3 films for reference dose measurements in the beam of a prototype high dose-per-pulse linear accelerator (linac), capable of delivering electron beams with a mean dose-rate (Ḋ ) ranging from 0.07 to 3000 Gy/s and a dose-rate in pulse (Ḋ ) of up to 8 × 10 Gy/s. To do this, we evaluated the overall uncertainties in EBT3 film dosimetry as well as the energy and dose-rate dependence of their response.

[Antifungal susceptibility of Candida spp. isolates from blood cultures in a five-year period (1997-2001)].

Introduction: This retrospective study investigates the incidence of candidemia and antifungal susceptibility of Candida spp. isolates from blood cultures performed in the period from January 1997 to December 2001.

Methods: Amphotericin B, fluconazole, itraconazole and flucytosine minimal inhibitory concentrations (MICs) were determined using the Sensititre YeastOne broth microdilution assay for the 53 isolates detected in the study period: C.

Cutaneous infection caused by Ulocladium chartarum in a heart transplant recipient: case report and review.

A cutaneous mycoses caused by Ulocladium chartarum in a heart transplant recipient is reported. The infection cleared after complete surgical excision and 6 months of oral itraconazole therapy. In vitro activity of amphotericin B, fluconazole, itraconazole, voriconazole, ravuconazole and terbinafine against the clinical isolate is shown.

Chromomycosis due to Exophiala jeanselmei in a renal transplant recipient.

Chromomycosis is a rare mycotic infection that is more frequent in tropical and subtropical regions. Dematiaceous fungi are the causal agents of this mycosis. Several cases of chromomycosis in organ transplant recipients have been reported.