Publications by authors named "Maria Teresa Di Stazio"
Article Synopsis
- Early detection of recurrences in gynecological cancers is vital, and circulating tumor DNA (ctDNA) analysis via liquid biopsy shows promise for monitoring disease progression.
- The study assessed the effectiveness of digital Polymerase Chain Reaction (dPCR) in detecting ctDNA in three patients with confirmed cancer relapses post-surgery, using patient-specific mutations identified through whole-exome sequencing.
- Results indicated that dPCR could detect increased ctDNA levels before traditional serum markers like CA125, but also highlighted the challenges of tumor heterogeneity, as one patient did not show ctDNA signals despite clinical signs of relapse.
Background And Objectives: The Italian Gruppo di Studio delle Piastrine recently developed a diagnostic algorithm to assist clinicians in the diagnosis of inherited thrombocytopenias. This algorithm is based on the simplest possible diagnostic investigations and can also be used in centers that are not highly specialized. The aim of the present study was to validate this diagnostic algorithm by applying it to a case series of genetic thrombocytopenias.
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