Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics.

Background: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.

Types of stroke recurrence in patients with ischemic stroke: a substudy from the PRoFESS trial.

Background: Risk profiles for stroke recurrence are poorly characterized.

Aims: We determined the variation in the risk and type of recurrent stroke among index ischemic stroke subtypes, and whether index stroke subtype and conventional stroke risk factors were predictors of stroke recurrence.

Methods: Patients enrolled in the Prevention Regimen for Effectively Avoiding Second Strokes trial were included in this study.

Pharmacogenetic testing for guiding de novo phenprocoumon therapy in stroke patients.

Background: For many conditions causing transient ischemic attack or minor stroke, secondary prevention with early initiation of oral anticoagulation is indicated. The individual response to coumarins is known to vary widely and is not well predicted by clinical variables. Patients' discharge from hospital care is often delayed only because the therapeutic target range has not been reached yet.