Nerve growth factor and its monocyte receptors are affected in kidney disease.

Nerve growth factor (NGF) plays a critical role in both physiological and pathological conditions. Their biological effects are mediated by two receptors (NGF-R): TrkA and p75. We previously reported NGF and NGF-R overexpression in various renal disorders.

Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application.

We investigated the effect of glaucoma (GL) on nerve growth factor (NGF) presence in two brain visual areas. Rats with elevated intraocular pressure (EIOP), induced by hypertonic saline injection in the episcleral vein, were treated with eye topical application of saline or NGF. Rats were subsequently sacrificed, and brain tissues were used for immunohistochemical, biochemical, and molecular analyses.

Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques.

Early stressful events can increase vulnerability for psychopathology, although knowledge on the effectors is still limited. Here we tested the hypothesis that peripheral levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are involved in the response to stress and in the pathophysiology of anxiety and depression, might be affected in a non-human primate model of adverse rearing. Males and females rhesus macaques reared with their mothers (MR) or in peer-only groups (PR) were used as experimental subjects.

Nerve growth factor (NGF) and NGF-receptor expression in diseased human kidneys.

Background: Nerve growth factor (NGF) has been indicated to be critical to normal renal development in rodents. However, little is known about the expression of NGF and the high-affinity NGF receptors in human kidneys which is essential for promoting the biological and functional activities of NGF. The present study examined the presence of NGF, low-affinity (p75) and high-affinity tyrosine kinase A (TrkA) NGF receptor (NGFR) immunoreactivity in diseased human kidneys.