Publications by authors named "Maria Teresa Abreu"
Recent evidence indicates that the gut microbiota (GM) has a significant impact on the inflammatory bowel disease (IBD) progression. Our aim was to investigate the GM profiles, the Microbial Dysbiosis Index (MDI) and the intestinal microbiota-associated markers in relation to IBD clinical characteristics and disease state. We performed 16S rRNA metataxonomy on both stools and ileal biopsies, metabolic dysbiosis tests on urine and intestinal permeability and mucosal immunity activation tests on the stools of 35 IBD paediatric patients.
View Article and Find Full Text PDFWilliams-Beuren syndrome (WBS) is a rare genetic neurodevelopmental disorder with multi-systemic manifestations. The evidence that most subjects with WBS face gastrointestinal (GI) comorbidities, have prompted us to carry out a metaproteomic investigation of their gut microbiota (GM) profile compared to age-matched healthy subjects (CTRLs). Metaproteomic analysis was carried out on fecal samples collected from 41 individuals with WBS, and compared with samples from 45 CTRLs.
View Article and Find Full Text PDFArticle Synopsis
- - Williams-Beuren syndrome (WBS) is a genetic disorder linked to a deletion on chromosome 7, causing various health issues like cardiovascular problems, growth issues, and gastrointestinal symptoms, largely influenced by the elastin gene.
- - This study conducted an exploratory analysis of gut microbiota in WBS patients, revealing significant dysbiosis with an increase in harmful bacteria and a decrease in beneficial ones compared to healthy controls.
- - The research implies that profiling gut microbiota could help manage WBS symptoms, suggesting that microbial treatments may enhance patient care and quality of life alongside traditional therapies.