Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans.

Context: Numerous factors are purported to influence insulin sensitivity including age, adiposity, mitochondrial function, and physical fitness. Univariate associations cannot address the complexity of insulin resistance or the interrelationship among potential determinants.

Objective: The objective of the study was to identify significant independent predictors of insulin sensitivity across a range of age and adiposity in humans.