Increased cholesterol absorption rather than synthesis is involved in boosted protease inhibitor-associated hypercholesterolaemia.

Objective: The aim of this study was to compare the differential effects of first-line efavirenz (EFV)-based vs. boosted lopinavir-based antiretroviral regimens on cholesterol metabolism.

Design: Multicentre, open-label, randomized clinical trial.

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial.

Background: The effects of ezetimibe on cholesterol metabolism in HIV-infected patients receiving boosted protease inhibitors have not been thoroughly assessed. The aim of this study was to assess cholesterol homeostasis in patients with PI associated dyslipidemia and its relationship with the response to treatment with the cholesterol-absorption inhibitor ezetimibe.

Methods: Fifteen patients with ritonavir-boosted PI-containig therapy and LDL-cholesterol > 3.

Preoperative nutritional status and post-operative infection in total knee replacements: a prospective study of 213 patients.

Purpose: To assess the potential relationship between preoperative nutritional status, including anthropometric parameters, and infection following total knee replacement surgery.

Methods: A total of 213 patients undergoing total knee replacement between December 2007 and May 2008 were prospectively studied. Patients with rheumatoid arthritis were excluded.