Publications by authors named "Maria T A Dendle"
Article Synopsis
- * Research shows that some unstable TTR variants are secreted in forms that can either remain as proper tetramers or convert into harmful oligomers.
- * Pharmacological treatments that improve protein stability in the endoplasmic reticulum help maintain TTR in its functional tetramer form, thereby reducing harmful aggregates; however, disrupting this balance results in more aggregation.
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduced amyloidogenesis. The efficacy of these inhibitors was enhanced further by installing an ethyl, a propyl, or a CF(3) group at the C(5) position.
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