Publications by authors named "Maria Sutter"
Article Synopsis
- Neuroblastoma is a dangerous cancer found in young children, and this study investigates the ability of mesenchymal stromal cells (MSCs) to target tumors due to their natural ability to home to them.* -
- In the study, 28 mice were implanted with neuroblastoma cells and injected with either placental-derived MSCs or bone marrow-derived MSCs to track their movement and presence in tumors.* -
- Results showed both MSC types effectively migrated to the tumor and remained detectable for up to 7 days, highlighting their potential to be used as delivery vehicles for cancer treatments, with no significant difference in their homing abilities.*
Article Synopsis
- Neuroblastoma, a common childhood cancer, shows poor outcomes in high-risk cases, prompting the investigation of mesenchymal stromal cells (MSCs) as potential delivery vehicles for treatment due to their tumor-homing abilities.
- The study compared the effects of placental MSCs (PMSCs) and bone marrow-derived MSCs (BM-MSCs) on the proliferation of neuroblastoma cells, using various in vitro assays to analyze their impact across different cell lines.
- Results indicated that BM-MSCs had a lower effect on neuroblastoma cell growth compared to PMSCs, with variations noted among different cell lines, suggesting that the choice of MSC source is important for optimizing drug delivery strategies in neuroblastoma treatment
Background/aim: Neuroblastoma is a common childhood cancer with poor survival for children with high-risk disease, and ongoing research to improve outcomes is needed. Patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM) are reliable models for oncologic research; however, they are resource-intensive, expensive, and require significant expertise to develop and maintain. We developed an orthotopic xenograft murine model of neuroblastoma that utilizes cryopreserved banks of human neuroblastoma cell lines, requires minimal equipment, and is easily reproducible.
View Article and Find Full Text PDFObjective: To summarize research to understand the priorities of consumers with spinal cord injury (SCI) as related to neuroprosthesis.
Materials And Methods: This review is generated from results presented during a session at the 2008 Neural Interfaces Conference held in Cleveland, OH including presentations of research, observation of a panel discussion, and a case study.
Results: Understanding priorities of consumers living with SCI may help guide development of technology to potentially increase quality of life, confidence, and independence.