Publications by authors named "Maria Sukhareva"
Article Synopsis
- - Innate immunity in invertebrates provides effective antimicrobial peptides (AMPs) that combat drug-resistant infections, sparking interest in finding new β-hairpin AMPs from worm proteins with a BRICHOS domain.
- - Researchers discovered new BRICHOS AMPs from caecilians, a lesser-known group of vertebrates, revealing similarities to lung surfactants and suggesting a unique lung function.
- - The identified peptides show strong antibacterial properties against multidrug-resistant ESKAPE pathogens while being low in toxicity, indicating potential as a new antibiotic model and highlighting a previously unrecognized lung immunity mechanism.
Thymalin is an immunomodulatory drug containing a polypeptide extract of thymus that has demonstrated efficacy in the therapy of acute respiratory distress syndrome and chronic obstructive pulmonary disease, as well as in complex therapy related to severe COVID-19 in middle-aged and elderly patients.. KE and EW dipeptides are active substances of Thymalin.
View Article and Find Full Text PDFThe need of the synthesis of a new generation of medicines aimed at combating bacteria and biofilms that cause various infections is a great urgency. There has been a gradual decrease in the conventional techniques of treatment with the use of antibiotics. Consequently, much effort has focused on the search for new methods and approaches to obtain antibacterial drugs and determine their rational use such that microorganisms do not acquire resistance.
View Article and Find Full Text PDFArticle Synopsis
- * The interaction between AMPs and antiseptics is less studied than AMPs and antibiotics, yet analyzing their combined antibacterial and cytotoxic activities reveals both synergistic and antagonistic effects.
- * Optimizing AMP/antiseptic combinations could enhance treatment efficacy, reduce toxicity, and limit bacterial resistance, but careful evaluation is needed to avoid potential interference that may diminish AMP effectiveness.
Article Synopsis
- - Proline-rich antimicrobial peptides (PR-AMPs) like ChBac3.4, isolated from goat leukocytes, show strong effectiveness against Gram-negative bacteria with low toxicity to human cells, making them promising for antibiotic development.
- - A study on ChBac3.4 explored its unique properties, antibacterial effectiveness against drug-resistant strains, and potential as a lead for both antimicrobial and anticancer therapies, while assessing how structural changes influenced toxicity and activity.
- - Findings revealed that modifications such as terminal amidation and increased hydrophobicity altered the peptides' effectiveness and side effects, highlighting a balance between antibacterial potency and selectivity towards tumor cells, while some variants exhibited unexpected toxicity toward human red blood cells.