Effectiveness of Hydroxychloroquine and Omalizumab in Chronic Spontaneous Urticaria: A Real-World Study.

Background: Chronic spontaneous urticaria (CSU) not controlled by optimized doses of antihistamines is referred to as refractory CSU. Add-on therapies recommended by guidelines include omalizumab, immunosuppressive, and anti-inflammatory agents.

Objectives: The objective of the study was to assess the real-world effectiveness of different add-on treatment options for refractory CSU in 2 large clinical practices.

On the incremental validity of irrational beliefs to predict subjective well-being while controlling for personality factors.

This research examines the incremental validity of irrational thinking as conceptualized by Albert Ellis to predict diverse aspects of subjective well-being while controlling for the influence of personality factors. Rational-emotive behavior therapy (REBT) argues that irrational beliefs result in maladaptive emotions leading to reduced well-being. Although there is some early scientific evidence for this relation, it has never been investigated whether this connection would still persist when statistically controlling for the Big Five personality factors, which were consistently found to be important determinants of well-being.

Be yourself, believe in yourself, and be happy: self-efficacy as a mediator between personality factors and subjective well-being.

Research has shown close connections between personality and subjective well-being (SWB), suggesting that personality traits predispose individuals to experience different levels of SWB. Moreover, numerous studies have shown that self-efficacy is related to both personality factors and SWB. Extending previous research, we show that general self-efficacy functionally connects personality factors and two components of SWB (life satisfaction and subjective happiness).